Fly agaric

Research corpus coverage

Chemistry notes

• Principal reported constituents include muscimol, ibotenic acid; broad class: GABA-A agonism and glutamatergic effects.

Traditional / historical use

Documented traditional use — not a claim of established efficacy.

No traditional-use records in this corpus.

Modern evidence

• Color varieties and related Amanita species are confused; deadly Amanita misidentification is a major hazard.

  MODERATE · Amanita muscaria: Ecology, Chemistry, Myths

  Identity/attribution caution.

Human

• Critical

  Safety severity is CRITICAL: delirium, seizures, coma, severe GI effects; species misidentification can be fatal

  Misidentification · HIGH · Amanita muscaria: Ecology, Chemistry, Myths

Dogs

• High risk

  Fatal Amanita muscaria poisoning has been reported in dogs following ingestion; a retrospective canine mushroom-ingestion evaluation identified two lethal cases associated with A. muscaria.

  Intrinsic toxicity · OTHER · whole mushroom; preparation unspecified · HIGH · regulatory_guidance · Scientific Memorandum: Amanita Muscaria (9/9/2024)

• High risk

  Ingestion of Amanita muscaria mushrooms has caused canine toxicosis, including somnolence, gastroenteritis, hypersalivation, miotic pupils, and generalized seizures; ibotenic acid and muscimol were confirmed in the reported dogs.

  Intrinsic toxicity · OTHER · whole mushroom · HIGH · regulatory_guidance · Scientific Memorandum: Amanita Muscaria (9/9/2024)

• Caution

  Ingestion of Amanita muscaria can cause isoxazole toxicosis affecting the central nervous system; the page classifies this syndrome as generally not life-threatening, with recovery typically reported within 4–24 hours.

  Intrinsic toxicity · OTHER · whole mushroom; preparation not specified · HIGH · veterinary_manual · Overview of Mushrooms Toxic to Animals - Toxicology

Cats & dogs

• High risk

  The page describes Amanita mushrooms as hepatotoxic; ingestion may initially cause gastrointestinal signs and later progress to liver failure, jaundice, weakness, lethargy, coma, and death.

  Intrinsic toxicity · OTHER · whole mushroom; wild mushroom · MODERATE · veterinary_hospital_guidance · Mushroom Toxicity

• High risk

  Amanita muscaria is described as a toxic or poisonous mushroom; ingestion-related poisoning is attributed principally to muscimol, ibotenic acid, and muscarine.

  Intrinsic toxicity · OTHER · whole mushroom; preparation unspecified · HIGH · regulatory_guidance · Scientific Memorandum: Amanita Muscaria (9/9/2024)

• High risk

  Ingestion of Amanita muscaria can cause isoxazole poisoning; muscimol is the major toxin associated with neurologic signs in animals.

  Intrinsic toxicity · OTHER · Mushroom; no specific preparation stated · HIGH · veterinary_manual · Toxin Latent Period ≤3 Hours After Ingestion of Mushrooms

Additional safety notes (general, unstructured)

Free-text safety notes carried from their source — not broken out by species, route, or hazard type, and not equivalent to the structured records above. Each note names the kind of source it came from.

• Safety severity is CRITICAL: delirium, seizures, coma, severe GI effects; species misidentification can be fatal

  HIGH · Amanita muscaria: Ecology, Chemistry, Myths

• The page describes Amanita mushrooms as hepatotoxic; ingestion may initially cause gastrointestinal signs and later progress to liver failure, jaundice, weakness, lethargy, coma, and death.

  MODERATE · veterinary_hospital_guidance · Mushroom Toxicity

  The page discusses Amanita mushrooms generally, including death-cap/death-angel mushrooms, and does not specifically identify Amanita muscaria.

• Amanita muscaria is described as a toxic or poisonous mushroom; ingestion-related poisoning is attributed principally to muscimol, ibotenic acid, and muscarine.

  HIGH · regulatory_guidance · Scientific Memorandum: Amanita Muscaria (9/9/2024)

  This passage provides a general dog-and-cat toxic characterization but no additional species-specific clinical findings.

• Ingestion of Amanita muscaria can cause isoxazole poisoning; muscimol is the major toxin associated with neurologic signs in animals.

  HIGH · veterinary_manual · Toxin Latent Period ≤3 Hours After Ingestion of Mushrooms

  The page provides animal-level information without cat- or dog-specific toxicity, dose, or preparation data.

• Fatal Amanita muscaria poisoning has been reported in dogs following ingestion; a retrospective canine mushroom-ingestion evaluation identified two lethal cases associated with A. muscaria.

  HIGH · regulatory_guidance · Scientific Memorandum: Amanita Muscaria (9/9/2024)

  The individual preparation and clinical details of the lethal cases were not stated.

• Ingestion of Amanita muscaria mushrooms has caused canine toxicosis, including somnolence, gastroenteritis, hypersalivation, miotic pupils, and generalized seizures; ibotenic acid and muscimol were confirmed in the reported dogs.

  HIGH · regulatory_guidance · Scientific Memorandum: Amanita Muscaria (9/9/2024)

• Ingestion of Amanita muscaria can cause isoxazole toxicosis affecting the central nervous system; the page classifies this syndrome as generally not life-threatening, with recovery typically reported within 4–24 hours.

  HIGH · veterinary_manual · Overview of Mushrooms Toxic to Animals - Toxicology

  The page states that dogs are particularly susceptible to mushroom toxicosis, but does not provide Amanita muscaria-specific dog-versus-cat clinical data.