Clove

Research corpus coverage

Chemistry notes

• CHEMISTRY: Relevant reported constituents include eugenol; beta-caryophyllene; constituent presence alone does not establish clinical efficacy.

Traditional / historical use

Documented traditional use — not a claim of established efficacy.

• TRADITIONAL: Clove has been used for toothache; digestive complaints; antisepsis; this records historical/traditional use and does not establish efficacy.

  MODERATE · regulatory monograph · WHO Monographs on Selected Medicinal Plants

Modern evidence

• EVIDENCE: For the major use set (toothache; digestive complaints; antisepsis), the evidence assessment is limited/mixed: Limited evidence for temporary topical dental analgesia; insufficient for systemic uses.

  MODERATE · regulatory monograph and mixed scientific literature · WHO Monographs on Selected Medicinal Plants

  Mixed findings, product heterogeneity, or indirect evidence are preserved in the detailed profile.

Forms used traditionally

A listed form does not imply it suits every plant part, or that one preparation is interchangeable with another — see the plant’s own notes below.

Cats

• High risk

  Clove oil is known to cause poisoning in cats and may produce neurologic, respiratory, cardiovascular, thermoregulatory, gastrointestinal, and hepatic signs.

  Intrinsic toxicity · OTHER · clove essential oil · HIGH · poison_control_database · Essential Oils and Cats

• High risk

  Clove oil is listed as an essential oil known to cause poisoning in cats after oral or dermal exposure.

  Intrinsic toxicity · OTHER · essential oil · HIGH · poison_control_database · Updates on Essential Oils

Cats & dogs

• High risk

  Clove oil is listed among essential oils associated with products that can be toxic in dogs and/or cats; the page does not provide oil-specific species, route, dose, or sign attribution.

  Intrinsic toxicity · OTHER · Essential oil, including as a component of herbal flea or tick treatments · MODERATE · veterinary_manual · essential, herbal, oil poisoning canine feline - Consultant

• High risk

  Clove essential oil is listed among common essential oils that can cause poisoning in animals.

  Intrinsic toxicity · OTHER · essential oil · HIGH · poison_control_database · Essential Oils | Pet Poison Helpline®

Additional safety notes (general, unstructured)

Free-text safety notes carried from their source — not broken out by species, route, or hazard type, and not equivalent to the structured records above. Each note names the kind of source it came from.

• SAFETY: Major issues include Concentrated oil can cause liver injury, seizures and coagulopathy; mucosal burns. Contraindications/cautions include Children; liver disease; bleeding disorders.

  HIGH · observational/case series and expert review · LiverTox: Herbal and Dietary Supplements

• SAFETY: Clinically relevant interaction concerns include Additive bleeding; hepatotoxic drugs.

  MODERATE · observational/case series and expert review · LiverTox: Herbal and Dietary Supplements

  Some interactions are theoretical or based on case reports/pharmacokinetics rather than outcome trials.

• SAFETY: Pregnancy/lactation reference: Avoid internal essential-oil use in pregnancy/lactation.

  MODERATE · regulatory monograph or evidence synthesis · WHO Monographs on Selected Medicinal Plants

  Absence of evidence is not evidence of safety.

• Clove oil is listed among essential oils associated with products that can be toxic in dogs and/or cats; the page does not provide oil-specific species, route, dose, or sign attribution.

  MODERATE · veterinary_manual · essential, herbal, oil poisoning canine feline - Consultant

  The page names clove oil but does not attribute the listed signs specifically to it or distinguish cats from dogs.

• Clove essential oil is listed among common essential oils that can cause poisoning in animals.

  HIGH · poison_control_database · Essential Oils | Pet Poison Helpline®

  No clove-specific toxic constituent, dose, route-specific profile, or sign profile is provided.

• Clove oil is known to cause poisoning in cats and may produce neurologic, respiratory, cardiovascular, thermoregulatory, gastrointestinal, and hepatic signs.

  HIGH · poison_control_database · Essential Oils and Cats

  The page names clove oil but does not identify its toxic constituent or distinguish route.

• Clove oil is listed as an essential oil known to cause poisoning in cats after oral or dermal exposure.

  HIGH · poison_control_database · Updates on Essential Oils

  The page does not list clove oil among the dog oils known to cause poisoning; this is not evidence of safety in dogs.

Taxonomic identity note

• Clove is treated here as Syzygium aromaticum (L.) Merr. & L.M.Perry in the family Myrtaceae; recorded older names include Eugenia caryophyllata Thunb..