Hops

Research corpus coverage

Chemistry notes

• CHEMISTRY: Relevant reported constituents include humulones; lupulones; 8-prenylnaringenin; constituent presence alone does not establish clinical efficacy.

Traditional / historical use

Documented traditional use — not a claim of established efficacy.

• TRADITIONAL: Hops has been used for sleep; nervousness; appetite; this records historical/traditional use and does not establish efficacy.

  MODERATE · regulatory monograph · WHO Monographs on Selected Medicinal Plants

Modern evidence

• EVIDENCE: For the major use set (sleep; nervousness; appetite), the evidence assessment is limited/mixed: Limited evidence, often in valerian combinations; single-herb efficacy uncertain.

  MODERATE · regulatory monograph and mixed scientific literature · WHO Monographs on Selected Medicinal Plants

  Mixed findings, product heterogeneity, or indirect evidence are preserved in the detailed profile.

Forms used traditionally

A listed form does not imply it suits every plant part, or that one preparation is interchangeable with another — see the plant’s own notes below.

Dogs

• High risk

  Ingestion of hops (Humulus lupulus) is toxic to dogs; dried hops plugs tend to be more toxic than hops pellets.

  Intrinsic toxicity · OTHER · dried hops plugs or pellets · HIGH · poison_control_database · Brewing Hops Poisonous To Pets

• High risk

  Certain dog breeds are identified as being at higher risk for hop toxicosis, including Greyhounds, Labrador Retrievers, Saint Bernards, Pointers, Dobermans, Border Collies, English Springer Spaniels, and northern breeds such as Alaskan and Siberian huskies.

  Intrinsic toxicity · OTHER · hops; preparation unspecified · HIGH · poison_control_database · Hops | American College of Veterinary Pharmacists

• High risk

  Ingestion of dried hops flowers can cause clinically important or potentially life-threatening hops toxicity in dogs.

  Intrinsic toxicity · OTHER · Dried flowers · HIGH · poison_control_database · Dogs + Beer: Getting to the Bottom of Hops Toxicity

• High risk

  Ingestion of hops pellets can cause clinically important or potentially life-threatening hops toxicity in dogs.

  Intrinsic toxicity · OTHER · Pellets · HIGH · poison_control_database · Dogs + Beer: Getting to the Bottom of Hops Toxicity

• High risk

  Ingestion of hops plugs can cause clinically important or potentially life-threatening hops toxicity in dogs.

  Intrinsic toxicity · OTHER · Plugs · HIGH · poison_control_database · Dogs + Beer: Getting to the Bottom of Hops Toxicity

• High risk

  Ingestion of unused hops can cause clinically important or potentially life-threatening hops toxicity in dogs.

  Intrinsic toxicity · OTHER · Unused hops · HIGH · poison_control_database · Dogs + Beer: Getting to the Bottom of Hops Toxicity

• High risk

  Ingestion of used or spent hops can cause clinically important or potentially life-threatening hops toxicity in dogs.

  Intrinsic toxicity · OTHER · Used (spent) hops · HIGH · poison_control_database · Dogs + Beer: Getting to the Bottom of Hops Toxicity

• High risk

  Ingestion of hops (Humulus lupulus) or beer-making hops pellets can cause life-threatening elevations in body temperature in dogs; the page does not name a toxic constituent.

  Intrinsic toxicity · OTHER · whole plant or beer-making pellets · HIGH · poison_control_database · The Top 10 Deadliest Pet Toxins - ASPCA

• High risk

  ASPCA lists hops (Humulus lupulus; family Cannabidaceae) as toxic to dogs. Reported clinical signs include panting, high body temperature, seizures, and death.

  Intrinsic toxicity · UNKNOWN · Not stated; no concentration or preparation distinction provided · HIGH · poison_control_database · Hops

• High risk

  Ingestion of common hops (Humulus lupulus) has caused toxicosis in dogs, including severe malignant hyperthermia, tachycardia, tachypnea, vomiting, diarrhea, agitation, or lethargy; signs develop within 8–24 hours and may last 24–48 hours.

  Intrinsic toxicity · OTHER · herbal supplement or plant material · HIGH · veterinary_manual · Toxicosis en animales por suplementos dietéticos y plantas ...

• High risk

  Ingestion of common hops has been reported to cause toxicosis in dogs; malignant hyperthermia can be severe and may be accompanied by tachycardia, tachypnea, vomiting, diarrhea, agitation, or lethargy.

  Intrinsic toxicity · OTHER · plant material; preparation not otherwise specified · HIGH · veterinary_manual · Toxicosis en animales por suplementos dietéticos y a base ...

• High risk

  Ingestion of common hops plant material can cause hops toxicosis in dogs; severe malignant hyperthermia, tachycardia, tachypnea, vomiting, diarrhea, agitation, or lethargy may develop. There are no reported cases in species other than dogs on this page.

  Intrinsic toxicity · OTHER · plant material used as an herbal supplement · HIGH · veterinary_manual · Toxicoses in Animals From Human Dietary and Herbal Supplements

• High risk

  Untreated hop poisoning can cause death in dogs within six hours of ingestion; any dog breed may be affected, with certain listed breeds at higher risk for malignant hyperthermia.

  Intrinsic toxicity · OTHER · hops; dried plugs or pellets · HIGH · poison_control_database · Brewing Hops Poisonous To Pets

• Caution

  Hops (Humulus lupulus) is listed under “Plants Toxic to Dogs.” No cat-specific evidence, toxic constituents, clinical signs, or preparation distinctions are provided.

  Intrinsic toxicity · UNKNOWN · Not stated; whole plant or plant group listing only · HIGH · poison_control_database · Toxic and Non-Toxic Plant List — Dogs - ASPCA

Cats & dogs

• High risk

  Ingestion of hops is classified as toxic to domestic animals; clinical signs may develop within minutes to hours, and fatality has been documented within 6 hours. No safe consumption level is identified on the page.

  Intrinsic toxicity · OTHER · hops; preparation unspecified · HIGH · poison_control_database · Hops | American College of Veterinary Pharmacists

• Caution

  ASPCA states that consumption of any plant material may cause vomiting and gastrointestinal upset in dogs and cats; this general statement is not a hops-specific toxicity designation.

  Intrinsic toxicity · ORAL · Plant material; preparation not stated · HIGH · poison_control_database · Poisonous Plants - ASPCA

Additional safety notes (general, unstructured)

Free-text safety notes carried from their source — not broken out by species, route, or hazard type, and not equivalent to the structured records above. Each note names the kind of source it came from.

• SAFETY: Major issues include Sedation; possible estrogenic effects; allergy. Contraindications/cautions include Hormone-sensitive conditions; depression caution.

  MODERATE · observational/case series and expert review · LiverTox: Herbal and Dietary Supplements

• SAFETY: Clinically relevant interaction concerns include Additive sedation and possible hormonal interactions.

  MODERATE · observational/case series and expert review · LiverTox: Herbal and Dietary Supplements

  Some interactions are theoretical or based on case reports/pharmacokinetics rather than outcome trials.

• SAFETY: Pregnancy/lactation reference: Avoid medicinal use in pregnancy/lactation.

  MODERATE · regulatory monograph or evidence synthesis · WHO Monographs on Selected Medicinal Plants

  Absence of evidence is not evidence of safety.

• Ingestion of hops is classified as toxic to domestic animals; clinical signs may develop within minutes to hours, and fatality has been documented within 6 hours. No safe consumption level is identified on the page.

  HIGH · poison_control_database · Hops | American College of Veterinary Pharmacists

  The page states that domestic animals are susceptible but provides no cat-specific evidence and does not identify a toxic constituent or preparation-specific risk.

• ASPCA states that consumption of any plant material may cause vomiting and gastrointestinal upset in dogs and cats; this general statement is not a hops-specific toxicity designation.

  HIGH · poison_control_database · Poisonous Plants - ASPCA

  The page does not assign these effects specifically to hops or identify a toxic constituent.

• Certain dog breeds are identified as being at higher risk for hop toxicosis, including Greyhounds, Labrador Retrievers, Saint Bernards, Pointers, Dobermans, Border Collies, English Springer Spaniels, and northern breeds such as Alaskan and Siberian huskies.

  HIGH · poison_control_database · Hops | American College of Veterinary Pharmacists

  The page does not specify a mechanism, toxic constituent, dose, or preparation-specific risk.

• Ingestion of dried hops flowers can cause clinically important or potentially life-threatening hops toxicity in dogs.

  HIGH · poison_control_database · Dogs + Beer: Getting to the Bottom of Hops Toxicity

  The page provides no cat-specific evidence and does not identify the toxic constituent.

• Ingestion of hops pellets can cause clinically important or potentially life-threatening hops toxicity in dogs.

  HIGH · poison_control_database · Dogs + Beer: Getting to the Bottom of Hops Toxicity

  The page provides no cat-specific evidence and does not identify the toxic constituent.

• Ingestion of hops plugs can cause clinically important or potentially life-threatening hops toxicity in dogs.

  HIGH · poison_control_database · Dogs + Beer: Getting to the Bottom of Hops Toxicity

  The page provides no cat-specific evidence and does not identify the toxic constituent.

• Ingestion of unused hops can cause clinically important or potentially life-threatening hops toxicity in dogs.

  HIGH · poison_control_database · Dogs + Beer: Getting to the Bottom of Hops Toxicity

  The page provides no cat-specific evidence and does not identify the toxic constituent.

• Ingestion of used or spent hops can cause clinically important or potentially life-threatening hops toxicity in dogs.

  HIGH · poison_control_database · Dogs + Beer: Getting to the Bottom of Hops Toxicity

  The page provides no cat-specific evidence and does not identify the toxic constituent.

• Ingestion of hops (Humulus lupulus) or beer-making hops pellets can cause life-threatening elevations in body temperature in dogs; the page does not name a toxic constituent.

  HIGH · poison_control_database · The Top 10 Deadliest Pet Toxins - ASPCA

  No cat-specific evidence, toxic constituent, concentration, or plant-family information is provided.

• Hops (Humulus lupulus) is listed under “Plants Toxic to Dogs.” No cat-specific evidence, toxic constituents, clinical signs, or preparation distinctions are provided.

  HIGH · poison_control_database · Toxic and Non-Toxic Plant List — Dogs - ASPCA

  Family is listed as Cannabidaceae.

• ASPCA lists hops (Humulus lupulus; family Cannabidaceae) as toxic to dogs. Reported clinical signs include panting, high body temperature, seizures, and death.

  HIGH · poison_control_database · Hops

  The page provides no cat-specific toxicity classification or clinical signs; this should not be interpreted as evidence of safety in cats.

• Ingestion of common hops (Humulus lupulus) has caused toxicosis in dogs, including severe malignant hyperthermia, tachycardia, tachypnea, vomiting, diarrhea, agitation, or lethargy; signs develop within 8–24 hours and may last 24–48 hours.

  HIGH · veterinary_manual · Toxicosis en animales por suplementos dietéticos y plantas ...

  The page reports intoxication only in dogs and does not report it in cats or other species.

• Ingestion of common hops has been reported to cause toxicosis in dogs; malignant hyperthermia can be severe and may be accompanied by tachycardia, tachypnea, vomiting, diarrhea, agitation, or lethargy.

  HIGH · veterinary_manual · Toxicosis en animales por suplementos dietéticos y a base ...

  The page reports intoxication in dogs only and provides no cat-specific evidence.

• Ingestion of common hops plant material can cause hops toxicosis in dogs; severe malignant hyperthermia, tachycardia, tachypnea, vomiting, diarrhea, agitation, or lethargy may develop. There are no reported cases in species other than dogs on this page.

  HIGH · veterinary_manual · Toxicoses in Animals From Human Dietary and Herbal Supplements

  Cat-specific evidence is not stated; the page reports no poisoning in species other than dogs.

• Ingestion of hops (Humulus lupulus) is toxic to dogs; dried hops plugs tend to be more toxic than hops pellets.

  HIGH · poison_control_database · Brewing Hops Poisonous To Pets

• Untreated hop poisoning can cause death in dogs within six hours of ingestion; any dog breed may be affected, with certain listed breeds at higher risk for malignant hyperthermia.

  HIGH · poison_control_database · Brewing Hops Poisonous To Pets

  The page lists Greyhounds, Labrador retrievers, Saint Bernards, Pointers, Dobermans, Border collies, English springer spaniels, and northern breeds as predisposed to malignant hyperthermia.

Taxonomic identity note

• Hops is treated here as Humulus lupulus L. in the family Cannabaceae; recorded older names include Humulus volubilis Salisb..