Neem

Research corpus coverage

Chemistry notes

• CHEMISTRY: Relevant reported constituents include azadirachtin; nimbolide; limonoids; constituent presence alone does not establish clinical efficacy.

Traditional / historical use

Documented traditional use — not a claim of established efficacy.

• TRADITIONAL: Neem has been used for skin disorders; oral hygiene; infections; this records historical/traditional use and does not establish efficacy.

  MODERATE · regulatory monograph · EMA European Union herbal monographs and list entries

Modern evidence

• EVIDENCE: For the major use set (skin disorders; oral hygiene; infections), the evidence assessment is limited/mixed: Limited human evidence for dental/topical uses; insufficient for systemic disease treatment.

  MODERATE · regulatory monograph and mixed scientific literature · EMA European Union herbal monographs and list entries

  Mixed findings, product heterogeneity, or indirect evidence are preserved in the detailed profile.

Forms used traditionally

A listed form does not imply it suits every plant part, or that one preparation is interchangeable with another — see the plant’s own notes below.

Cats & dogs

• High risk

  Neem (margosa) oil is listed among essential oils associated with products that can be toxic in dogs and/or cats; the page does not provide oil-specific species, route, dose, or sign attribution.

  Intrinsic toxicity · OTHER · Essential oil, including as a component of herbal flea or tick treatments · MODERATE · veterinary_manual · essential, herbal, oil poisoning canine feline - Consultant

Additional safety notes (general, unstructured)

Free-text safety notes carried from their source — not broken out by species, route, or hazard type, and not equivalent to the structured records above. Each note names the kind of source it came from.

• SAFETY: Major issues include Neem oil ingestion can cause severe metabolic, neurologic and hepatic toxicity, especially in children. Contraindications/cautions include Infants/children; pregnancy; liver/kidney disease.

  HIGH · observational/case series and expert review · LiverTox: Herbal and Dietary Supplements

• SAFETY: Clinically relevant interaction concerns include Potential additive glucose lowering and immunomodulation.

  MODERATE · observational/case series and expert review · LiverTox: Herbal and Dietary Supplements

  Some interactions are theoretical or based on case reports/pharmacokinetics rather than outcome trials.

• SAFETY: Pregnancy/lactation reference: Avoid internal use in pregnancy; lactation safety is insufficient.

  MODERATE · regulatory monograph or evidence synthesis · EMA European Union herbal monographs and list entries

  Absence of evidence is not evidence of safety.

• Neem (margosa) oil is listed among essential oils associated with products that can be toxic in dogs and/or cats; the page does not provide oil-specific species, route, dose, or sign attribution.

  MODERATE · veterinary_manual · essential, herbal, oil poisoning canine feline - Consultant

  The page names neem oil but does not attribute the listed signs specifically to it or distinguish cats from dogs.

Taxonomic identity note

• Neem is treated here as Azadirachta indica A.Juss. in the family Meliaceae; recorded older names include Melia azadirachta L..