Tobacco

Research corpus coverage

Chemistry notes

• Principal reported constituents include nicotine, nornicotine; broad class: nicotinic acetylcholine receptor agonists.

Traditional / historical use

Documented traditional use — not a claim of established efficacy.

No traditional-use records in this corpus.

Modern evidence

• Commercial tobacco should not be collapsed into sacred tobacco traditions; species and additives differ.

  MODERATE · Indigenous-Amazonian Traditional Medicine’s Usage of the Tobacco Plant: A Transdisciplinary Ethnopsychological Mixed-Methods Case Study

  Identity/attribution caution.

Human

• Critical

  Safety severity is CRITICAL: dependence, cardiovascular disease, cancer and acute nicotine poisoning

  Intrinsic toxicity · HIGH · Indigenous-Amazonian Traditional Medicine’s Usage of the Tobacco Plant: A Transdisciplinary Ethnopsychological Mixed-Methods Case Study

Cats

• High risk

  Cats exposed to thirdhand tobacco-smoke particles on their fur can ingest the particles during grooming, with increased risk of aggressive oral squamous cell carcinoma.

  Route-specific · OTHER · Thirdhand smoke residue deposited on fur · HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

• High risk

  Cats living in smoking households have increased risk of lymphoma from tobacco-smoke exposure through inhalation and grooming-related ingestion of thirdhand particles.

  Route-specific · INHALATION · Secondhand smoke and thirdhand smoke residue · HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

• High risk

  Secondhand tobacco smoke is harmful to cats and is associated with increased risk of lymphoma; cats living with people who smoke more than one pack of cigarettes daily have three times the risk described on the page.

  Route-specific · INHALATION · Secondhand tobacco smoke from smoking · HIGH · regulatory_guidance · El humo de segunda mano y su mascota - FDA

• High risk

  FDA reports that chronic secondhand tobacco-smoke exposure is harmful to cats and is associated with increased lymphoma risk; third-hand residue may also be ingested during grooming.

  Route-specific · INHALATION · smoke/combustion · HIGH · regulatory_guidance · Secondhand (and Third-Hand) Smoke May Be Making Your Pet Sick

• High risk

  The page’s general toxicity-to-pets text describes tobacco (Nicotiana) poisoning as causing initial low heart and respiratory rates, followed by overstimulation, uncontrolled urination or defecation, tremors, seizures, paralysis, and death; it does not separately assign a toxicity designation to cats.

  Intrinsic toxicity · UNKNOWN · Tobacco and related nicotine-containing products; no preparation-specific distinction provided · MODERATE · poison_control_database · Tobacco Is Toxic To Dogs | Pet Poison Helpline®

• Caution

  Nicotine ingestion may cause acute toxicosis in cats, but the page states that no established toxic threshold exists for cats.

  Intrinsic toxicity · OTHER · nicotine or nicotine-containing tobacco products · HIGH · poison_control_database · Nicotine & Tobacco | American College of Veterinary Pharmacists

• Caution

  Environmental tobacco smoke exposure was associated with increased risk of malignant lymphoma in pet cats.

  Route-specific · INHALATION · Environmental tobacco smoke · MODERATE · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier ...

Dogs

• High risk

  Nicotine ingestion can cause clinically important acute toxicosis in dogs; the page states that a dose of 9–12 mg/kg is considered lethal.

  Intrinsic toxicity · OTHER · nicotine or nicotine-containing tobacco products · HIGH · poison_control_database · Nicotine & Tobacco | American College of Veterinary Pharmacists

• High risk

  Chronic inhalation of tobacco smoke is associated with increased risk of nasal cancer in long-nosed dogs and lung cancer in short- and medium-nosed dogs.

  Route-specific · INHALATION · Inhaled tobacco smoke · HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

• High risk

  A dog died from nicotine poisoning after eating an electronic cigarette capsule.

  Intrinsic toxicity · OTHER · Electronic cigarette capsule · HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier ...

• High risk

  Nicotine ingestion is dangerous in dogs.

  Intrinsic toxicity · OTHER · Nicotine-containing tobacco product; specific preparation not stated · HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier ...

• High risk

  Secondhand tobacco smoke is harmful to dogs; risk of nasal or lung cancer varies with nose length, and some breeds have higher risk.

  Route-specific · INHALATION · Secondhand tobacco smoke from smoking · HIGH · regulatory_guidance · El humo de segunda mano y su mascota - FDA

• High risk

  FDA reports that chronic secondhand tobacco-smoke exposure is harmful to dogs and is associated with nasal or lung cancer.

  Route-specific · INHALATION · smoke/combustion · HIGH · regulatory_guidance · Secondhand (and Third-Hand) Smoke May Be Making Your Pet Sick

• High risk

  The page states that tobacco (Nicotiana) is toxic to dogs. Nicotine and other pyridine and piperidine alkaloids may cause initial bradycardia and respiratory depression, followed by overstimulation, uncontrolled urination or defecation, tremors, seizures, paralysis, and death.

  Intrinsic toxicity · UNKNOWN · Tobacco and related nicotine-containing products; no preparation-specific distinction provided · HIGH · poison_control_database · Tobacco Is Toxic To Dogs | Pet Poison Helpline®

• Caution

  Exposure to environmental tobacco smoke was associated with cancer of the nasal cavity and paranasal sinuses in pet dogs.

  Route-specific · INHALATION · Environmental tobacco smoke · MODERATE · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier ...

• Caution

  Passive exposure to environmental cigarette smoke was associated with airway limitation in dogs with chronic cough.

  Route-specific · INHALATION · Environmental cigarette smoke · MODERATE · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier ...

Cats & dogs

• Contraindicated

  Exposure to electronic nicotine-delivery systems, nicotine capsules, or liquid refilling solution can cause nicotine poisoning; prompt veterinary evaluation is advised.

  Intrinsic toxicity · INHALATION · Electronic nicotine-delivery devices, capsules, cartridges, and liquid nicotine refills · HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

• Contraindicated

  Ingestion of cigarettes, cigarette butts, cigars, chewing tobacco, nicotine refill capsules, or liquid nicotine refilling solution can cause serious nicotine poisoning and is described as a veterinary emergency.

  Intrinsic toxicity · OTHER · Tobacco products and nicotine-containing refill products · HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

• High risk

  Ingestion of tobacco-derived nicotine in e-liquid or other nicotine-containing products can cause rapid, potentially severe nicotine poisoning in companion animals; severe cases may result in coma, cyanosis, or death.

  Intrinsic toxicity · OTHER · E-liquid, pre-filled cartridges, bulk refill bottles, cigarettes, cigars, nicotine patches, or nicotine gum · MODERATE · veterinary_hospital_guidance · E-cigarettes and Pet Safety | VCA Animal Hospitals

• High risk

  Ingestion of nicotine-containing tobacco products, including chewing tobacco, cigarettes, cigars, bidis, nicotine-replacement products, and cigarette butts, may be toxic to cats and dogs.

  Intrinsic toxicity · OTHER · tobacco products and nicotine preparations · HIGH · poison_control_database · Nicotine & Tobacco | American College of Veterinary Pharmacists

• High risk

  Secondhand tobacco smoke exposure is harmful to dogs and cats; the page states that there is no risk-free level of exposure.

  Route-specific · INHALATION · Secondhand smoke from exhaled smoke and a lit tobacco product · HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

• High risk

  Thirdhand tobacco-smoke residues on skin, clothing, furniture, carpets, dust, and fur can be ingested by dogs and cats through licking or grooming; the residues are harmful to pets.

  Route-specific · OTHER · Thirdhand tobacco-smoke residue on objects, people, dust, carpets, or fur · HIGH · regulatory_guidance · El humo de segunda mano y su mascota - FDA

• High risk

  Ingestion of tobacco products containing nicotine can cause rapid nicotine poisoning in dogs and cats; signs may include vomiting, diarrhea, agitation, increased heart and respiratory rates, depression, tremors, ataxia, weakness, seizures, cyanosis, coma, and cardiac arrest.

  Intrinsic toxicity · OTHER · Tobacco products, including cigarettes, vaping products, chewing tobacco, and nicotine gum · HIGH · poison_control_database · Nicotine Poisoning Symptoms in Pets

Additional safety notes (general, unstructured)

Free-text safety notes carried from their source — not broken out by species, route, or hazard type, and not equivalent to the structured records above. Each note names the kind of source it came from.

• Safety severity is CRITICAL: dependence, cardiovascular disease, cancer and acute nicotine poisoning

  HIGH · Indigenous-Amazonian Traditional Medicine’s Usage of the Tobacco Plant: A Transdisciplinary Ethnopsychological Mixed-Methods Case Study

• Ingestion of tobacco-derived nicotine in e-liquid or other nicotine-containing products can cause rapid, potentially severe nicotine poisoning in companion animals; severe cases may result in coma, cyanosis, or death.

  MODERATE · veterinary_hospital_guidance · E-cigarettes and Pet Safety | VCA Animal Hospitals

  The page refers to tobacco-derived nicotine but does not identify the botanical tobacco species; applicability to Nicotiana tabacum is therefore not species-specific.

• Ingestion of nicotine-containing tobacco products, including chewing tobacco, cigarettes, cigars, bidis, nicotine-replacement products, and cigarette butts, may be toxic to cats and dogs.

  HIGH · poison_control_database · Nicotine & Tobacco | American College of Veterinary Pharmacists

  The page discusses tobacco and nicotine products generally and does not identify Nicotiana tabacum botanically or distinguish it from Nicotiana rustica.

• Exposure to electronic nicotine-delivery systems, nicotine capsules, or liquid refilling solution can cause nicotine poisoning; prompt veterinary evaluation is advised.

  HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

  The page discusses tobacco-derived nicotine products generally and does not identify a Nicotiana species.

• Ingestion of cigarettes, cigarette butts, cigars, chewing tobacco, nicotine refill capsules, or liquid nicotine refilling solution can cause serious nicotine poisoning and is described as a veterinary emergency.

  HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

  The page discusses tobacco products generally and does not identify a Nicotiana species.

• Secondhand tobacco smoke exposure is harmful to dogs and cats; the page states that there is no risk-free level of exposure.

  HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

  The page discusses tobacco generally and does not identify a Nicotiana species; this claim is mapped to the canonical tobacco entry.

• Thirdhand tobacco-smoke residues on skin, clothing, furniture, carpets, dust, and fur can be ingested by dogs and cats through licking or grooming; the residues are harmful to pets.

  HIGH · regulatory_guidance · El humo de segunda mano y su mascota - FDA

  The page does not specify clinical signs, affected organs, dose, concentration, or a particular tobacco species.

• Ingestion of tobacco products containing nicotine can cause rapid nicotine poisoning in dogs and cats; signs may include vomiting, diarrhea, agitation, increased heart and respiratory rates, depression, tremors, ataxia, weakness, seizures, cyanosis, coma, and cardiac arrest.

  HIGH · poison_control_database · Nicotine Poisoning Symptoms in Pets

  The page discusses tobacco products and nicotine but does not identify a botanical tobacco species; mapped to Nicotiana tabacum as the canonical tobacco entry. It does not provide species-specific differences between dogs and cats.

• Nicotine ingestion may cause acute toxicosis in cats, but the page states that no established toxic threshold exists for cats.

  HIGH · poison_control_database · Nicotine & Tobacco | American College of Veterinary Pharmacists

  The page provides no cat-specific dose or threshold and does not botanically distinguish Nicotiana tabacum from other tobacco sources.

• Cats exposed to thirdhand tobacco-smoke particles on their fur can ingest the particles during grooming, with increased risk of aggressive oral squamous cell carcinoma.

  HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

  The page discusses tobacco generally and does not identify a Nicotiana species.

• Cats living in smoking households have increased risk of lymphoma from tobacco-smoke exposure through inhalation and grooming-related ingestion of thirdhand particles.

  HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

  The page discusses tobacco generally and does not identify a Nicotiana species.

• Environmental tobacco smoke exposure was associated with increased risk of malignant lymphoma in pet cats.

  MODERATE · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier ...

  The page names tobacco/environmental tobacco smoke but does not identify the tobacco species; this claim is mapped provisionally to common tobacco.

• Secondhand tobacco smoke is harmful to cats and is associated with increased risk of lymphoma; cats living with people who smoke more than one pack of cigarettes daily have three times the risk described on the page.

  HIGH · regulatory_guidance · El humo de segunda mano y su mascota - FDA

  The page discusses tobacco smoke rather than a botanically identified tobacco species; the stated smoking exposure is an epidemiologic risk comparison, not a toxicity threshold.

• FDA reports that chronic secondhand tobacco-smoke exposure is harmful to cats and is associated with increased lymphoma risk; third-hand residue may also be ingested during grooming.

  HIGH · regulatory_guidance · Secondhand (and Third-Hand) Smoke May Be Making Your Pet Sick

  Tobacco-specific evidence; grooming creates a feline third-hand exposure route.

• The page’s general toxicity-to-pets text describes tobacco (Nicotiana) poisoning as causing initial low heart and respiratory rates, followed by overstimulation, uncontrolled urination or defecation, tremors, seizures, paralysis, and death; it does not separately assign a toxicity designation to cats.

  MODERATE · poison_control_database · Tobacco Is Toxic To Dogs | Pet Poison Helpline®

  The clinical signs are presented in general pet text rather than separately attributed to cats; the page discusses Nicotiana generally and does not provide species-specific evidence for Nicotiana tabacum.

• Nicotine ingestion can cause clinically important acute toxicosis in dogs; the page states that a dose of 9–12 mg/kg is considered lethal.

  HIGH · poison_control_database · Nicotine & Tobacco | American College of Veterinary Pharmacists

  The dose information concerns nicotine generally, not a botanically identified Nicotiana tabacum product.

• Chronic inhalation of tobacco smoke is associated with increased risk of nasal cancer in long-nosed dogs and lung cancer in short- and medium-nosed dogs.

  HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier Lives | FDA

  The page reports breed-morphology-associated cancer risks but does not identify a Nicotiana species.

• A dog died from nicotine poisoning after eating an electronic cigarette capsule.

  HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier ...

  The capsule was identified as causing nicotine poisoning, but the page does not identify the tobacco species or capsule composition beyond nicotine.

• Exposure to environmental tobacco smoke was associated with cancer of the nasal cavity and paranasal sinuses in pet dogs.

  MODERATE · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier ...

  The page names tobacco/environmental tobacco smoke but does not identify the tobacco species; this claim is mapped provisionally to common tobacco.

• Nicotine ingestion is dangerous in dogs.

  HIGH · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier ...

  The page names nicotine rather than a specific tobacco species or product.

• Passive exposure to environmental cigarette smoke was associated with airway limitation in dogs with chronic cough.

  MODERATE · regulatory_guidance · Be Smoke-free and Help Your Pets Live Longer, Healthier ...

  The page names tobacco/environmental cigarette smoke but does not identify the tobacco species; this claim is mapped provisionally to common tobacco.

• Secondhand tobacco smoke is harmful to dogs; risk of nasal or lung cancer varies with nose length, and some breeds have higher risk.

  HIGH · regulatory_guidance · El humo de segunda mano y su mascota - FDA

  The page discusses tobacco smoke rather than a botanically identified tobacco species and does not provide a toxicity threshold.

• FDA reports that chronic secondhand tobacco-smoke exposure is harmful to dogs and is associated with nasal or lung cancer.

  HIGH · regulatory_guidance · Secondhand (and Third-Hand) Smoke May Be Making Your Pet Sick

  Tobacco-specific evidence; do not automatically transfer the cancer association to every burned herb.

• The page states that tobacco (Nicotiana) is toxic to dogs. Nicotine and other pyridine and piperidine alkaloids may cause initial bradycardia and respiratory depression, followed by overstimulation, uncontrolled urination or defecation, tremors, seizures, paralysis, and death.

  HIGH · poison_control_database · Tobacco Is Toxic To Dogs | Pet Poison Helpline®

  The page discusses Nicotiana generally and does not provide species-specific evidence for Nicotiana tabacum.